Nonanimal Alternatives for Skin Sensitization: A Step Forward?

Determining epidermal disposition kinetics for use in an integrated nonanimal approach to skin sensitization risk assessment.

Development of risk assessment methods for skin sensitization in the absence of toxicological data generated in animals represents a major scientific and technical challenge. The first step in human skin sensitization induction is the transport of sensitizer from the applied dose on the skin surface to the epidermis, where innate immune activation occurs. Building on the previous development of...

One step forward

[A step forward].

Nos gustaría comenzar esta nueva etapa agradeciendo a Elsevier y al anterior equipo editorial su esfuerzo, su constancia y su contribución al desarrollo de la Enfermería desde que comenzaron su andadura en el año 2004. Sin duda, Enfermería Clínica ha brindando a los enfermeros y enfermeras la posibilidad de colaborar en un objetivo común: el avance de la profesión para poder ofrecer nuestra mej...

A step forward for Brazilian pediatric research.

doi:10.2223/JPED.1451 Brazilian pediatric research appears to be healthy, or at least its ability to get published is improving. Two optimistic reports by Blank et al. contrast with the pessimism expressed in my home country of the United Kingdom. Last year Jornal de Pediatria reported that SciELO indexing had led to an increase in local submissions to the journal while MEDLINE indexing had res...

one step forward

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